Biopharmaceutical Process Optimization with Simulation and Scheduling Tools

Petridis, Dimitris/ Koulouris, Alexandros/ Siletti, Charles/ Carmichael, Doug/ Κουλούρης, Αλέξανδρος/ Πετρίδης, Δημήτρης

Institution and School/Department of submitter: ΤΕΙ Θεσσαλονίκης
Keywords: Bioprocess development;Βιοφαρμακευτική επεξεργασία;Βιοχημική προσομοίωση;Biopharmaceutical process;Βιοχημική ανάπτυξη;Bioprocess simulation
Issue Date: 29-Sep-2014
Publisher: MDPI AG
Citation: Petrides, D., Carmichael, D., Siletti, C. & Koulouris, A. (Σεπτέμβριος 2014). Biopharmaceutical Process Optimization with Simulation and Scheduling Tools. Bioengineering. 1(4):154-187.
Journal : Bioengineering, vol. 1, no. 4, 2014
Abstract: Design and assessment activities associated with a biopharmaceutical process are performed at different levels of detail, based on the stage of development that the product is in. Preliminary “back-of-the envelope” assessments are performed early in the development lifecycle, whereas detailed design and evaluation are performed prior to the construction of a new facility. Both the preliminary and detailed design of integrated biopharmaceutical processes can be greatly assisted by the use of process simulators, discrete event simulators or finite capacity scheduling tools. This report describes the use of such tools for bioprocess development, design, and manufacturing. The report is divided into three sections. Section One provides introductory information and explains the purpose of bioprocess simulation. Section Two focuses on the detailed modeling of a single batch bioprocess that represents the manufacturing of a therapeutic monoclonal antibody (MAb). This type of analysis is typically performed by engineers engaged in the development and optimization of such processes. Section Three focuses on production planning and scheduling models for multiproduct plants.
Description: Δημοσιεύσεις μελών--ΣΤΕΤ-Δ--Τμήμα Τεχνολογίας Τροφίμων--2014
ISSN: 2306-5354
Other Identifiers:
Item type: other
Submission Date: 2018-02-28T16:08:55Z
Item language: el
Item access scheme: free
Institution and School/Department of submitter: ΤΕΙ Θεσσαλονίκης
Appears in Collections:Δημοσιεύσεις σε Περιοδικά

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