Biopharmaceutical Process Optimization with Simulation and Scheduling Tools

Petridis, Dimitris/ Koulouris, Alexandros/ Siletti, Charles/ Carmichael, Doug/ Κουλούρης, Αλέξανδρος/ Πετρίδης, Δημήτρης

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dc.contributor.authorPetridis, Dimitrisel
dc.contributor.authorKoulouris, Alexandrosel
dc.contributor.authorSiletti, Charlesel
dc.contributor.authorCarmichael, Dougel
dc.contributor.otherΚουλούρης, Αλέξανδροςel
dc.contributor.otherΠετρίδης, Δημήτρηςel
dc.identifier.citationPetrides, D., Carmichael, D., Siletti, C. & Koulouris, A. (Σεπτέμβριος 2014). Biopharmaceutical Process Optimization with Simulation and Scheduling Tools. Bioengineering. 1(4):154-187.el
dc.identifier.citationJournal : Bioengineering, vol. 1, no. 4, 2014el
dc.descriptionΔημοσιεύσεις μελών--ΣΤΕΤ-Δ--Τμήμα Τεχνολογίας Τροφίμων--2014el
dc.description.abstractDesign and assessment activities associated with a biopharmaceutical process are performed at different levels of detail, based on the stage of development that the product is in. Preliminary “back-of-the envelope” assessments are performed early in the development lifecycle, whereas detailed design and evaluation are performed prior to the construction of a new facility. Both the preliminary and detailed design of integrated biopharmaceutical processes can be greatly assisted by the use of process simulators, discrete event simulators or finite capacity scheduling tools. This report describes the use of such tools for bioprocess development, design, and manufacturing. The report is divided into three sections. Section One provides introductory information and explains the purpose of bioprocess simulation. Section Two focuses on the detailed modeling of a single batch bioprocess that represents the manufacturing of a therapeutic monoclonal antibody (MAb). This type of analysis is typically performed by engineers engaged in the development and optimization of such processes. Section Three focuses on production planning and scheduling models for multiproduct plants.el
dc.publisherMDPI AGel
dc.rightsΤο τεκμήριο πιθανώς υπόκειται σε σχετική με τα Πνευματικά Δικαιώματα νομοθεσίαel
dc.rightsThis item is probably protected by Copyright Legislationel
dc.subjectBioprocess developmentel
dc.subjectΒιοφαρμακευτική επεξεργασίαel
dc.subjectΒιοχημική προσομοίωσηel
dc.subjectBiopharmaceutical processel
dc.subjectΒιοχημική ανάπτυξηel
dc.subjectBioprocess simulationel
dc.subject.lcshΒιοχημική μηχανική--Σχεδίαση με τη βοήθεια ηλεκτρονικού υπολογιστή--Μελέτες περίπτωσηςel
dc.subject.lcshΠρόγραμμα παραγωγήςel
dc.subject.lcshProduction schedulingel
dc.subject.lcshBiochemical engineering--Computer-aided design--Case studiesel
dc.titleBiopharmaceutical Process Optimization with Simulation and Scheduling Toolsel
heal.recordProviderΤΕΙ Θεσσαλονίκηςel
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