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This postgraduate thesis aims to describe the principles of destination management based on international literature review and to explore the functionality or applicability of these principles in practice in the region of Central Macedonia. This region has a particularly high potential for the development in tourism sector for the next five years. In this selected region (Region of Central Macedonia - RCM, Greece), we investigated whether there is a Destination Management Organization (DMO) and how much it participates in the management and organization of the tourism product of RCM and in the effective development of the region's tourism in general. In order to achieve the aim of the research, a secondary research of relevant literature review on a global scale took place in addition to a primary survey using in depth interviews of tourism stakeholders. With the establishment of a new tourism organization for the whole area of RCM, such as a Destination Management Organization, RCM might have been viewed as a qualified and organized destination that would be much more attractive to tourists. To date, destination management is carried out by local government administrations such as the cities of Thessaloniki and Edessa, and the Region of Central Macedonia or by associations of tourism professionals such as the Halkidiki Tourism Organization. These organizations are geographically limited and have their own priorities and prerequisites for the development of tourism, creating and displaying specific products or product packages that do not include the full range of the RCM tourism product. In a highly competitive environment such as the tourism industry, tourism destinations must be treated and organized in a professional manner. To ensure this, it is necessary to create and successfully operate a Destination Management Organization that will be supported and financed by the total public administrative authorities and private partners of the destination